Taking Psilocybin at a Macro-dose level, usually defined as between 2 and 3.5 grams of dried psilocybin mushrooms, has been shown in many scientifically meticulous studies to reliably produce spiritual, mystical, or transcendent experiences that have lasting positive effect on the subject. Studies at Harvard, Stanford, Yale, University of Toronto, and Johns Hopkins have begun to realize the drastic benefits of psilocybin in treating numerous psychological conditions. In addition to its remarkable effectiveness in treating depression, anxiety, and addiction, psilocybin also has the potential to radically improve the well-being and happiness of 'healthy' individuals. 

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Humans can scientifically quantify many aspects of psilocybin metabolization, however we still lack crucial information as to why the bonding of psilocin with various 5HT receptors is able to produce metaphysical effects that are consistent across individuals of greatly varied backgrounds.